2026.08－至    今：中国科学院上海营养与健康研究所 研究员

2021.08－2026.07：中国科学院脑科学与智能技术卓越创新中心 博士后

2018.05－2020.04：芝加哥大学生物科学部 博士联合培养

2014.09－2021.06：中国科学院分子细胞科学卓越创新中心 博士

2010.09－2014.06：山东大学生命科学学院 学士

1.  Liansheng Zhang#, Qi Ma#, Xiangrui Kong#, Weijuan Zou#, Bo Wang#, Bin Wu#, Shicheng Cai, Tao Bai, Runlin Tan, Ziji Dai, Xingyu Liu, Zhiheng Jia, Meimei Zhang, Tianwen Li, Yuanyi Zheng*, Xinde Hu*, Jianrong Wu*, Zhengzheng Xu*, Haibo Zhou*. Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq. Science. 2026;392(6796):eadw2156. doi:10.1126/science.adw2156

2.  Liansheng Zhang#,*, Xiangrui Kong#, Qi Ma#, Xinde Hu#,*, Shicheng Cai#, Bo Wang#, Weijuan Zou, Tao Bai, Meimei Zhang, Liu Fan, Runlin Tan, Ziji Dai, Zhiheng Jia, Tianwen Li, Xingyu Liu, Huatai Xu, Jianrong Wu, Yuanyi Zheng, Zhengzheng Xu*, Haibo Zhou*. Linking GWAS risk genes to transcriptional features of major depressive disorder via in vivo Perturb-seq. Nature Genetics. 2026. doi:10.1038/s41588-026-02638-3

3.  Liansheng Zhang#,*, Zhengzheng Xu#, Zhiheng Jia#, Shicheng Cai#, Qiang Wu, Xingyu Liu, Xinde Hu, Tao Bai, Yongyu Chen, Tianwen Li, Zhen Liu, Bin Wu, Jianhong Zhu, Haibo Zhou*. Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration. Nature Aging. 2025;5(3):468-485. doi:10.1038/s43587-024-00792-z.

4.  Liansheng Zhang#, Zhiheng Jia#, Qiang Wu#, Tao Bai, Bo Wang, Xinde Hu, Tianwen Li, Xingyu Liu, Jiqiang Fu, Yuelei Chen, Xiaoyan Ding, Zhen Liu, Zhengzheng Xu*, Haibo Zhou*. Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice. Nature Metabolism. 2023;5(10):1787-1802. doi:10.1038/s42255-023-00887-8.

5.  Liansheng Zhang, Yun Qian, Jie Li, Xuan Zhou, He Xu, Jie Yan, Jialing Xiang, Xiang Yuan, Beicheng Sun, Sangram S Sisodia, Yong-Hui Jiang, Xiaohua Cao, Naihe Jing*, Anning Lin*. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. iScience, 2021;24(9):102942. doi:10.1016/j.isci.2021.102942.

6.  Liansheng Zhang#,*, Jie Li#, Anning Lin*. Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice. STAR Protocols. 2021;2(4):100915. doi:10.1016/j.xpro.2021.100915.

7.  Tianwen Li#, Liansheng Zhang#, Peng Wang#, Jingyu Yu#, Junjie Zhong#, Qisheng Tang, Tongming Zhu, Kezhu Chen, Fengshi Li, Pengjie Hong, Jiachen Wei, Xicai Sun, Guangchao Ji, Bin Song*, Jianhong Zhu*. Extracellular vesicles from neural stem cells safeguard neurons in intracerebral hemorrhage by suppressing reactive astrocyte neurotoxicity. Cell Reports. 2024;43(10):114854. doi:10.1016/j.celrep.2024.114854.

8.  Tianwen Li#, Liansheng Zhang#, Tao Lu#, Tongming Zhu#, Canbin Feng, Ni Gao, Fei Liu, Jingyu Yu, Kezhu Chen, Junjie Zhong, Qisheng Tang, Quan Zhang, Xiangyang Deng, Junwei Ren, Jun Zeng, Haibo Zhou*, Jianhong Zhu*. Engineered extracellular vesicle-delivered CRISPR/CasRx as a novel RNA editing tool. Advanced Science. 2023;10(10):e2206517. doi:10.1002/advs.202206517.

9.  Jie Li#, Liansheng Zhang#, Yongwei Zheng, Rui Shao, Qianqian Liang, Weida Yu, Hongyan Wang, Weiguo Zou, Demin Wang, Jialing Xiang, Anning Lin*. BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages. eLife. 2020;9:e56309. doi:10.7554/eLife.56309.

10. Jie Li#, Jie Li#, Jing Cao#, ShenShen Shang#, Liansheng Zhang, Fei Gao, Jiqiang Fu, Hongyu Chen, Guizhong Cui, Haoyuan Wu, Xiaolong Wang*, Alfonso Martinez-Arias*, Qiang Sun*, Zhen Liu*. Modelling late gastrulation in stem cell-derived monkey embryo models. Nature. 2026;649(8095):161-172. doi:10.1038/s41586-025-09831-0.

11. Jing Cao#, Wenjuan Li#, Jie Li#, Md Abdul Mazid#, Chunyang Li#, Yu Jiang#, Wenqi Jia, Liang Wu, Zhaodi Liao, Shiyu Sun, Weixiang Song, Jiqiang Fu, Yan Wang, Yong Lu, Yuting Xu, Yanhong Nie, Xinyan Bian, Changshan Gao, Xiaotong Zhang, Liansheng Zhang, Shenshen Shang, Yunpan Li, Lixin Fu, Hao Liu, Junjian Lai, Yang Wang, Yue Yuan, Xin Jin, Yan Li, Chuanyu Li, Yiwei Lai, Xuyang Shi, Patrick H Maxwell, Xun Xu, Longqi Liu, Muming Poo, Xiaolong Wang, Qiang Sun*, Miguel A Esteban*, Zhen Liu*. Live birth of chimeric monkey with high contribution from embryonic stem cells. Cell. 2023;186(23):4996-5014.e24. doi:10.1016/j.cell.2023.10.005.

12. Jie Li#, Qingyuan Zhu#, Jing Cao#, Ying Liu#, Yong Lu#, Yining Sun, Qian Li, Yiming Huang, Shenshen Shang, Xinyan Bian, Chunyang Li, Liansheng Zhang, Yan Wang, Yanhong Nie, Jiqiang Fu, Wenjuan Li, Md Abdul Mazid, Yu Jiang, Wenqi Jia, Xiaolong Wang, Yidi Sun, Miguel A Esteban, Qiang Sun*, Fan Zhou*, Zhen Liu*. Cynomolgus monkey embryo model captures gastrulation and early pregnancy. Cell Stem Cell. 2023;30(4):362-377.e7. doi:10.1016/j.stem.2023.03.009.

13. Anliang Xia#, Wenwen Yuan#, Qiang Wang#, Jianbo Xu#, Yayun Gu, Liansheng Zhang, Chen Chen, Zhangding Wang, Di Wu, Qifeng He, Weiwei Yu, Fei Wang, Cailin Xue, Yan Zhang, Guojian Bao, Xuewen Tao, Siyuan Liu, Shouyu Wang*, Zhibin Hu*, Beicheng Sun*. The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcription. Nature Cancer. 2022;3(2):203-218. doi:10.1038/s43018-021-00315-4.

14. Wenjie Zhang#, Guangyan Zhangyuan#, Fei Wang#, Kangpeng Jin, Haiyuan Shen, Liansheng Zhang, Xiang Yuan, Jincheng Wang, Haitian Zhang, Weiwei Yu, Ruyi Huang, Xiaoliang Xu, Yin Yin, Guisheng Zhong, Anning Lin*, Beicheng Sun*. The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation. Immunity. 2021;54(6):1168-1185.e8. doi:10.1016/j.immuni.2021.04.027.

（1）研究组长期招聘博士后，招聘方向包括但不限于细胞生物学、生物化学与分子生物学、神经生物学、计算生物学等相关专业。以第一作者身份发表过高水平研究论文者将优先考虑。

（2）欢迎对本研究组研究方向感兴趣的硕博连读生、直博生和外博生加入团队。