邮箱: weijunpan@sinh.ac.cn
电话: +86-21-54923309
研究组主页: http://weijunpanlab.renjucs.com
所属部门: 营养代谢与食品安全重点实验室
2020-04至 今：中国科学院上海营养与健康研究所 研究员（二级）、研究组长、博士生导师
2011-12至2020-03：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所 研究员、研究组长、博士生导师
2009-04至2011-08：美国国立卫生研究院 博士后 （合作导师: Brant M. Weinstein）
2005-02至2009-03：耶鲁大学 医学院药理系 博士后 （合作导师: Dianqing Wu）
1999-09至2004-10：中国科学院上海生命科学研究院生物化学与细胞生物学研究所 分子生物学与生物化学专业 博士 （导师：李林）
1995-09至1999-07：华东理工大学 生物化学专业-生物工程学院 学士
组织器官稳态、代谢及再生修复的在体解析
实验室致力于开发和应用最前沿的多尺度成像技术平台，将光学成像与体电子显微学（vEM）等多种模态的成像手段有机整合，实现从组织器官到亚细胞结构的跨尺度、高分辨率动态观测。在此基础上，结合活体荧光标记、遗传谱系示踪以及精准的遗传操控等技术，在完整的活体生理环境中，对复杂生物学过程开展系统性研究。我们关注的核心科学问题包括：机体如何感知并修复生理性损伤？营养物质和能量如何在不同组织器官之间动态运输与合理分配？造血系统与免疫系统如何协同维持机体的功能稳态？这些问题不仅是当前生命科学领域的前沿热点，也直接关系到人类健康与疾病发生的根本机制。与此同时，我们深入探索组织器官如何在生命周期中维持结构完整性和功能稳态，以及衰老和相关疾病如何逐步破坏这一精细平衡。通过揭示其中的动态分子调控网络，希望为开发靶向干预策略和再生修复方案提供新的理论依据和技术路径。
1. Jiao K.#; Chen X.#; Cao M.#; Zhang J.#; Xia X.; Gu X.; Wang X.; Zhong H.; Yue D.; Gao M.;Cheng N.; Luo S.; Yu W.; Pan W.*; Zhao C.*; Wang T.*; Zhu W.*; Xi J.*Translation of GGC repeats into a toxic polyglycine protein in oculopharyngodistal myopathy type 2. Brain. 2026, 149(5):1768-1783.
2. Qu, D.#; Li, Y.#; Liu, Q.#; Cao, B.; Cao, M.; Lin, X.; Shen, C.; Zou, P.; Zhou, H.*; Zhang, W.*; Pan, W.* Photoactivated SOPP3 enables APEX2-mediated proximity labeling with high spatio-temporal resolution in live cells. Cell Res. 2025, 35, 149-152.
3. Liu S.#; Li Q.#; Cao M.#; Zhao ZB.#; Liu C.; Zhen Z.; Ren J.; Liu C.; Ruan D.; Zhang L.; Zhang W.; Gong H.; Liu X.; Zhang X.; Pan D.; Pan W.*; Zhu J.* The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis. Mol. Cell. 2025, 85: 4587-4601.
4. Zhang, W.; Wu, S.; Li, Y.; Cao, M.; Cao, B.; Li, D.; Chen, K.*; Zhao, J.*; Pan, W.* Characterization of Zebrafish Alas2 Reporter for Study on Erythropoiesis, Blood Flow and Erythroid Disease. J. Genet. Genomics. 2025, 52: 958-961.
5. Zhang, W.; Liu, X.; Xue, W.; Gao, L.; Li, D.; Jing, C.*; Zhao, J.*; Pan, W.* Permissive role of CTCF-Hoxb7a-Cdkn2a/b axis in the emergence of hematopoietic stem and progenitor cells during zebrafish embryogenesis. J. Genet. Genomics. 2024, 51, 974-977.
6. Wu, S.#; Chen, K.#; Xu, T.#; Ma, K.; Gao, L.; Fu, C.; Zhang, W.; Jing, C.; Ren, C.; Deng, M.; Chen, Y.; Zhou, Y.; Pan, W.*; Jia, X.* Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Front. Cell Dev. Biol. 2021, 9, 709923.
7. Liu, X.; Zhang, W.; Jing, C.; Gao, L.; Fu, C.; Ren, C.; Hao, Y.; Cao, M.; Ma, K.*; Pan, W.*; Li, D.* Mutation of Gemin5 Causes Defective Hematopoietic Stem/Progenitor Cells Proliferation in Zebrafish Embryonic Hematopoiesis. Front. Cell Dev. Biol. 2021, 9, 670654.
8. Wang, L.#; Fan, J.#; Han, L.#; Qi, H.#; Wang, Y.; Wang, H.; Chen, S.; Du, L.; Li, S.; Zhang, Y.; Tang, W.; Ge, G.; Pan, W.*; Hu, P.*; Cheng, H.* The Micropeptide LEMP Plays an Evolutionarily Conserved Role in Myogenesis. Cell Death Dis. 2020, 11 (5), 357.
9. Zhao, W.#; Cao, L.#; Ying, H.#; Zhang, W.; Li, D.; Zhu, X.; Xue, W.; Wu, S.; Cao, M.; Fu, C.; Qi, H.; Hao, Y.; Tang, Y.-C.; Qin, J.; Zhong, T. P.; Lin, X.; Yu, L.; Li, X.; Li, L.; Wu, D.; Pan, W.* Endothelial CDS2 Deficiency Causes VEGFA-Mediated Vascular Regression and Tumor Inhibition. Cell Res. 2019, 29 (11), 895-910. （封面论文）
10. Li, D.#; Xue, W.#; Li, M.#; Dong, M.; Wang, J.; Wang, X.; Li, X.; Chen, K.; Zhang, W.; Wu, S.; Zhang, Y.; Gao, L.; Chen, Y.; Chen, J.; Zhou, B. O.; Zhou, Y.; Yao, X.; Li, L.; Wu, D.; Pan, W.* VCAM-1+ Macrophages Guide the Homing of HSPCs to a Vascular Niche. Nature. 2018, 564, 119-124.（封面论文）
11. He, X.#; Zhang, W.#; Yan, C.#; Nie, F.; Li, C.; Liu, X.; Fei, C.; Li, S.; Song, X.; Jia, Y.; Zeng, R.; Wu, D.; Pan, W.*; Hao, X.*; Li, L.* Chemical Biology Reveals CARF as a Positive Regulator of Canonical Wnt Signaling by Promoting TCF/β-Catenin Transcriptional Activity. Cell Discov. 2017,3, 17003.
12. Jia, X.-E.#; Ma, K.#; Xu, T.#; Gao, L.; Wu, S.; Fu, C.; Zhang, W.; Wang, Z.; Liu, K.; Dong, M.; Jing, C.; Ren, C.; Dong, Z.; Chen, Y.; Jin, Y.; Huang, Q.; Chang, X.; Deng, M.; Li, L.; Luo, L.; Zhu, J.; Dang, Y.; Chang, H.-C.; Zon, L. I.; Zhou, Y.*; Chen, S.*; Pan, W.* Mutation of Kri1l Causes Definitive Hematopoiesis Failure via PERK-Dependent Excessive Autophagy Induction. Cell Res. 2015, 25 (8), 946-962.
13. Gao, L.; Li, D.; Ma, K.; Zhang, W.; Xu, T.; Fu, C.; Jing, C.; Jia, X.-E.; Wu, S.; Sun, X.; Dong, M.; Deng, M.; Chen, Y.; Zhu, W.; Peng, J.; Wan, F.; Zhou, Y.; Zon, L. I.; Pan, W.* TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLOS Genet. 2015, 11 (7), e1005346.
14. Ren, C.-G.*; Wang, L.; Jia, X.-E.; Liu, Y.-J.; Dong, Z.-W.; Jin, Y.; Chen, Y.; Deng, M.; Zhou, Y.; Zhou, Y.; Ren, R.-B.; Pan, W.*; Liu, T.-X. Activated N-Ras Signaling Regulates Arterial-Venous Specification in Zebrafish. J. Hematol. Oncol. 2013, 6 (1), 34.
15. Kim, I.#; Pan, W.#*; Jones, S. A.#; Zhang, Y.; Zhuang, X.; Wu, D.* Clathrin and AP2 Are Required for PtdIns(4,5)P2-Mediated Formation of LRP6 Signalosomes. J. Cell Biol. 2013, 200 (4), 419-428.
16. Pan, W.#; Pham, V. N.#; Stratman, A. N.; Castranova, D.; Kamei, M.; Kidd, K. R.; Lo, B. D.; Shaw, K. M.; Torres-Vazquez, J.; Mikelis, C. M.; Gutkind, J. S.; Davis, G. E.; Weinstein, B. M.* CDP-Diacylglycerol Synthetase-Controlled Phosphoinositide Availability Limits VEGFA Signaling and Vascular Morphogenesis. Blood. 2012, 120 (2), 489-498.
17. Pan, W.#; Choi, S.#; Wang, H.#; Qin, Y.; Volpicelli-Daley, L.; Swan, L.; Lucast, L.; Khoo, C.; Zhang, X.; Li, L.; Abrams, C. S.; Sokol, S. Y.; Wu, D.* Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation. Science. 2008, 321 (5894), 1350-1353.
18. Pan, W.#; Jia, Y.#; Huang, T.; Wang, J.; Tao, D.; Gan, X.; Li, L.* β-Catenin Relieves I-Mfa-Mediated Suppression of LEF-1 in Mammalian Cells. J. Cell Sci. 2006, 119 (23), 4850-4856.
19. Pan, W.#; Jia, Y.#; Wang, J.; Tao, D.; Gan, X.; Tsiokas, L.; Jing, N.; Wu, D.*; Li, L.* β-Catenin Regulates Myogenesis by Relieving I-Mfa-Mediated Suppression of Myogenic Regulatory Factors in P19 Cells. Proc. Natl. Acad. Sci. 2005, 102 (48), 17378-17383.
20. Pan, W.#; Pang, S.#; Huang, T.; Guo, H.; Wu, D.; Li, L.* Characterization of Function of Three Domains in Dishevelled-1: DEP Domain Is Responsible for Membrane Translocation of Dishevelled-1. Cell Res. 2004, 14 (4), 324-330.
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