邮箱: zszhou@sinh.ac.cn
电话: +86-21-54920106
所属部门: 营养代谢与食品安全重点实验室
2021-至 今：中国科学院上海营养与健康研究所 研究员
2016-2021年：美国密歇根大学医学院博士后
2015-2016年：武汉大学生命科学学院 助理研究员
2009-2015年：中国科学院上海生命科学研究院生化与细胞所 博士
2004-2008年：山东大学生命科学学院 学士
细胞器互作稳态与代谢调控
真核细胞拥有多种功能特异的细胞器，细胞器间通过膜接触位点实现动态互作网络，是维持细胞稳态、保障机体正常生理代谢的核心基础。研究组聚焦细胞器互作稳态与代谢性疾病发病机制研究，依托高通量筛选、多组学分析和三维结构重构等前沿技术体系，结合基因编辑修饰、代谢性疾病动物模型等研究手段，深入探究细胞器互作稳态的代谢调控机制，揭示其失衡诱发代谢紊乱的分子机理。研究旨在阐明肥胖、2型糖尿病、慢性肝病等代谢性疾病的发病机制，为疾病的精准靶向干预、临床防治及药物研发提供坚实的理论基础。
1. Peng Q, Wang S, Zhang Y, Luo Y, Lan B, Wang N, Jiao W, Xie Z, Yuan Y, Duan W, Sun H, Yang P, Li Z, Ji Y, Gao Y, Zhou B, Yang L, Jiang Y, Lu M, Feng Y*, Zhou Z*. Hepatocyte hnRNPK preserves mitochondrial integrity to restrain liver injury and fibrosis. Hepatology 2026, online. DOI: 10.1097/HEP.0000000000001836
2. Zhao Y#, Zhou Y#, Pan L#, Tian GG, Huang HY, Tang S, Lu M, Zhou Z, Zhang P, Chen L, Zhang L, Hu L, Ji H*. Therapy-induced cholesterol biosynthesis drives lung cancer dormancy and drug resistance. J Clin Invest. 2026 Apr 15;136(8):e191735.
3. Luo Y#*, Sun M#, Chang L#, He Z, Zhou X, Yuan Y, Sun H, Luo S, Huang J, Wu H, Liu W, Zhou Z, Mao Y, Ji Y*, Liang T*. IRE1α translational suppression potentiates STING-dependent chemoresistance in pancreatic cancer. Cell Death Dis. 2025 Oct 6;16(1):680.
4. Zhao L, He Z, Sun Y, Sun M, Liu Z, Zhou Z, Qi L, Luo Y*, Ji Y*, Liang T*. Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling. Nat Commun. 2025 Dec 10;17(1):525.
5. Liu Q#, Wu X#, Duan W, Pan X, Wabitsch M, Lu M, Li J, Huang LH, Zhou Z, Zhu Y*. ACAT1/SOAT1 maintains adipogenic ability in preadipocytes by regulating cholesterol homeostasis. J Lipid Res. 2024 Dec;65(12):100680.
6. Ji Y*, Luo Y, Wu Y, Sun Y, Zhao L, Xue Z, Sun M, Wei X, He Z, Wu SA, Lin LL, Lu Y, Chang L, Chen F, Chen S, Qian W, Xu X, Chen S, Pan D, Zhou Z, Xia S, Hu CA, Liang T, Qi L*. SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool. Nat Cell Biol. 2023 May;25(5):726-739.
7. Yoshida S#, Wei X#, Zhang G#, O'Connor CL, Torres M, Zhou Z, Lin L, Menon R, Xu X, Zheng W, Xiong Y, Otto E, Tang CA, Hua R, Verma R, Mori H, Zhang Y, Hu CA, Liu M, Garg P, Hodgin JB, Sun S, Bitzer M, Qi L*.Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function. J Clin Invest. 2021 Apr 1;131(7):e143988.
8. Zhou Z#, Torres M#, Sha H, Halbrook CJ, Van den Bergh F, Reinert RB, Yamada T, Wang S, Luo Y, Hunter AH, Wang C, Sanderson TH, Liu M, Taylor A, Sesaki H, Lyssiotis CA, Wu J, Kersten S, Beard DA, Qi L*. Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes. Science. 2020 Apr 3;368(6486):54-60.
9. Zhou ZS#, Li MX#, Liu J#, Jiao H, Xia JM, Shi XJ, Zhao H, Chu L, Liu J, Qi W, Luo J, Song BL*.Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2. Nat Commun. 2020 Jan 17;11(1):379.
10. Li N, Zhou ZS, Shen Y, Xu J, Miao HH, Xiong Y, Xu F, Li BL, Luo J, Song BL* . Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice. Hepatology.2017 Jun;65(6):1936-1947.
11. Xie C#, Zhou ZS#, Li N, Bian Y, Wang YJ, Wang LJ, Li BL*, Song BL* . Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine. J Lipid Res. 2012 Oct;53(10):2092-2101.
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