组学，生物信息，染色体变异

通过开发和整合各种组学技术，实验室聚焦于分析基因组变异对癌症等疾病的影响；分析癌症性别差异的分子机理以及探索可能的治疗方案。

主要的研究方向为：

（1）整合多种组学数据，分析Y染色体丢失对癌症以及克隆性造血进程的影响；

（2）通过基因组变异以及转录组等数据，分析癌症中不同性别差异的分子机理；

（3）探索癌症新型治疗方案和开发新药；

（4）开发二代测序以及单细胞测序染色体变异相关的计算方法，衡量染色体变异的进化以及对疾病的影响。

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2. Zhang S, Zhang Z, Wang L, Qi M*. Loss of chromosome Y in hematopoietic cells: mechanisms and implications for human disease. MedScience 2026;20(3):397‑417.

3. Qi M, Pang J, Mitsiades I, Lane AA, Rheinbay E*. Loss of chromosome Y in primary tumors. Cell 2023 Jul;186(14):3125-3136.e11.

4. Rheinbay E, Qi M, Bouyssou JM, Oler AJ, Thumm L, Makiya M, et al. Genomics of PDGFR-rearranged hypereosinophilic syndrome. Blood Advances 2023 Jun 13;7(11):2558-2563.

5. Qi M, Nayar U, Ludwig LS, Wagle N, Rheinbay E*. cDNA-detector: detection and removal of cDNA contamination in DNA sequencing libraries. BMC Bioinformatics 2021 Dec;22(1):611.

6. Qi M#, Li Z#, Liu C, Hu W, Ye L, Xie Y, Zhuang Y, Zhao F, Teng W, Zheng Q, Fan Z, Xu L, Lang Z, Tong Y, Zhang Y*. CGT-seq: epigenome-guided de novo assembly of the core genome for divergent populations with large genome. Nucleic Acids Res 2018 Oct 12;46(18):e107.

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