邮箱: lxzhan@sinh.ac.cn
电话: +86-21-54920978
所属部门: 营养代谢与食品安全重点实验室
2017-至 今：中国科学院上海营养与健康研究所 研究员
2010-2016年：中国科学院上海生命科学研究院营养科学研究所 研究员
2004-2010年：美国冷泉港实验室 博士后
1998-2003年：中国人民解放军第二军医大学 内科学专业 博士
1991-1996年：浙江医科大学 临床医学专业 学士
上皮稳态失衡与肿瘤
1. 上皮极性/稳态调控与肿瘤
聚焦上皮极性基因的功能机制，系统解析以下四方面的细胞生物学问题：（1）极性信号在上皮稳态维持中的核心作用；（2）极性信号与亚细胞结构功能调控（例如线粒体和细胞骨架）的关系以及在上皮细胞能量代谢中的作用；（3）具有双定位功能的极性信号行使入核调控功能的重要意义；（4）探究基质刚度、组织压力等力学微环境破坏上皮细胞功能、并促进肿瘤进展的力学生物学机制。通过以上四方面的研究，解析极性蛋白丢失协同致癌突变驱动肿瘤发生的代谢重构以及肿瘤微环境调控的机制。
2. 硒稳态失衡与肿瘤发生
深入研究微量元素硒及硒蛋白家族因子在肿瘤氧化代谢压力下的多层次调控规律，通过线粒体蛋白调控细胞死亡、炎症以及与免疫代谢中全新机制探讨，试图解析肿瘤代谢重编程以及表观遗传调控规律，以明确其在肿瘤恶性转化中通过对肿瘤细胞衰老等方式实现改善肿瘤免疫微环境的免疫抑制作用，将为硒抗肿瘤免疫干预提供新的临床治疗干预方案和新靶点。
3. 上皮稳态与肝胰代谢性疾病
以肝胰上皮屏障为核心，研究上皮屏障紊乱与糖脂代谢微环境的相互调控机制，解析慢性代谢疾病中的免疫 - 代谢串扰规律，揭示肝屏障功能异常介导的以下病理生理过程：脂肪干细胞趋化分化等功能失衡、代谢紊乱与慢性免疫代谢微环境的关系及其炎症的分子基础，从而发掘慢性肝病及代谢综合征防治的新靶标与新策略。
1. Jiazheng Jiao, Lele Song, Shengjun Xu, Yuan Xue, Yanyan Liao, Keying Xu, Qian Wen, Kai Xiang, Rongrong Chen, Xiaoxia Dong, Yinlong Guo, Gang Li*, Haibiao Bao*, Xiao Xu*, Lixing Zhan*. Selenoprotein P Deficiency Drives Hepatocellular Carcinoma Progression via Induction of Neutrophil Senescence and Immunosuppressive Microenvironment. Gut. 2026, online. doi: 10.1136/gutjnl-2025-336422
2. Keying Xu, Xiaoxia Dong, Huiheng Qu, Jiayang Hu, Jiazheng Jiao, Rongrong Chen, Gang Li*, Zhaoshen Li*, Xiao Xu*, Jiazeng Xia*, and Lixing Zhan*. AF6 knockout-induced upregulation of bile acid production promotes CXCL14-mediated antitumor immunity in HCC. Journal of Hepatology. 2026, 84(5): 976-992.
3. Yingchao Liu, Jiahui Bai, Xiaoxia Dong, Yuqi Cao, Mingmai Bao, Yingjie Lu, Hui Zeng, Lixing Zhan*, Yinlong Guo*. Online Charge-Generation Derivatization by Electrochemical Radical Cations of Thianthrene: Mass Spectrometry Imaging of Estrogens in Biological Tissues. Analytical Chemistry. 2024, 96, 30, 12473–12481.
4. Xiuqi Gui, Jing Huang, Linjie Ruan, Yanjun Wu, Xuan Guo, Ruifang Cao, Shuhan Zhou, Fengxiang Tan, Hongwen Zhu, Mushan Li, Guoqing Zhang, Hu Zhou, Lixing Zhan*, Xin Liu*, Shiqi Tu*, Zhen Shao*. zMAP toolset: model-based analysis of large-scale proteomic data via a variance stabilizing z-transformation. Genome Biol. 2024, 25(1): 267.
5. Xinyu Wang, Qian Wen, Yanjun Wu, Jingwen Kong, Keying Xu, Jiazheng Jiao, Haibing Zhang*, Kai Wang*, Xiao Xu*, Lixing Zhan*. Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases. Cell Death and Disease, 2023, 14:673.
6. Yanjun Wu, Lele Song, Jingwen Kong, Qian Wen, Jiazheng Jiao, Xinyu Wang, Gang Li, Xiao Xu*, Lixing Zhan*. Scribble promotes fibrosis-dependent mechanisms of hepatocarcinogenesis by p53/PUMA-mediated glycolysis. Biochim Biophys Acta Mol Basis Dis, 2023, 1869(8):166823.
7. Meiyan Qi, Yun Xia, Yanjun Wu, Zhuo Zhang, Xinyu Wang, Liying Lu, Cheng Dai, Yanan Song, Keying Xu, Weiwei Ji, Lixing Zhan*. Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Nature Communications, 2022, 13:897.
8. Lele Song, Renxu Chang, Xia Sun; Liying Lu, Han Gao, Huiying Lu, Ritian Lin, Xiaorong Xu, Zhanju Liu*, Lixing Zhan*. Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice, Communications Biology. 2021, 4(1): 213.
9. Cheng Dai, Xinyu Wang, Yanjun Wu, Yi Xu, Shu Zhuo, Meiyan Qi, Weiwei Ji, Lixing Zhan*. Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in a SHP2-dependent Manner. Diabetes. 2019, 68:1577-1590.
10. Na Wang, Lele Song, Yi Xu, Longfu Zhang, Yanjun Wu, Jingyu Guo, Weiwei Ji, Li Li, Jingya Zhao, Xin Zhang*, Lixing Zhan*. Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling. EBioMedicine. 2019,47:65-77.
11. Renxu Chang, Lele Song, Yi Xu, Yanjun Wu, Cheng Dai, Xinyu Wang, Xia Sun, Yingyong Hou, Wei Li, Xiaobao Zhan, Zhan,Lixing*, Loss of Wwox drives metastasis 1 in triple-negative breast cancer by upregulating the IL6/JAK2/STAT3 axis, Nature Communications. 2018, 9:3486.
12. Xiaojiao Li, Lele Song, Xingjie Hu, Chang Liu, Jiye Shi, Hui Wang*, Lixing Zhan*, Haiyun Song*. Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles, ACS Appl Mater Interfaces, 2018, 10(4): 3449-3458.
13. Yi Zhou, Renxu Chang, Weiwei Ji, Na Wang, Meiyan Qi, Yi Xu, Jingyu Guo, Lixing Zhan *. Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance. Journal of Biological Chemistry. 2016, 291(1):291-302.
14. Yi Xu, Renxu Chang, Zhiyong Peng, Yanmei Wang, Weiwei Ji, Jingyu Guo, Lele Song, Cheng Dai, Wei Wei, Yanjun Wu, Xinjian Wan, Chenghao Shao, Lixing Zhan*. Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression. Nat Commun. 2015, 6:7184.
15. Lixing Zhan, Avi Rosenberg, Kenneth C Bergami, Min Yu, Zhenyu Xuan, Aron B Jaffe, Craig Allred, Senthil K Muthuswamy*. Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma. Cell. 2008, 135(5):865-78.
16. Lixing Zhan, Bin Xiang, Senthil K. Muthuswamy*.Controlled Activation of ErbB1/ErbB2 Heterodimers Promote Invasion of Three-Dimensional Organized Epithelia in an ErbB1-Dependent Manner: Implications for Progression of ErbB2-Overexpressing Tumor. Cancer Res. 2006, 66(10):5201-5208.
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