张国庆

张国庆

博士
生物医学大数据中心执行主任

邮箱: gqzhang@sinh.ac.cn

电话: +86-21-54920465

所属部门: 计算生物学重点实验室

个人简历

  2017-至  今:中国科学院上海营养与健康研究所 生物医学大数据中心,研究员
  2016-2017年:中国科学院上海生命科学研究院 生物医学大数据中心,研究员
  2006-2016年:上海生物信息技术研究中心 生命科学数据中心,部门主管
   

研究方向

    生物医学大数据、人工智能

研究内容

  1. 生物医学大数据治理关键技术研发
  2. 生物医学高质量数据集与语料构建
  3. 智能体及生物大模型运用

代表论著(#第一作者,*通讯作者)

1. Yujie Chen, Mengyao Han, Jiayue Meng, Dongjian Cao, Nianhao Cheng, Qingming Luo, Jie Yang, Guoqing Zhang*.Mouse Forebrain Region Features and Cholinergic Neurons Subtyping: Integrated Analysis with Spatial Multi-omics. Genomics Proteomics Bioinformatics. 2025 Nov 20:qzaf110. doi: 10.1093/gpbjnl/qzaf110.

2. Wei Chen, Yanpeng An, Ziru Chen, Ruijin Luo, Qinwei Lu, Cong Li, Chenhan Zhang, Qingxia Huang, Qinsheng Chen, Lianglong Zhang, Xiaoxuan Yi, Yixue Li*, Huiru Tang* and Guoqing Zhang*.TraceMetrix: a traceable metabolomics interactive analysis platform. Journal of Cheminformatics 17, 148 (2025).

3. Hanwen Zhou#, Yue Hu#*, Yulong Zheng, Jiefu Li, Jielong Peng, Jiang Hu, Yun Yang, Wei Chen, Guoqing Zhang*, Zefeng Wang*. A foundation language model to decipher diverse regulation of RNAs. Genome Biology. 26, 301 (2025).

4. 张国庆*, 刘婉, 吴祉乐, 周成效, 李强, 沈东婧, 赵国屏. 水圈微生物组大数据平台:驱动数据密集型研究范式转型的体系化实践. 生命科学, 2025, 37(10): 1203-1211. DOI: 10.13376/j.cbls/20250116.

5. Jiayue Meng#, Mengyao Han#, Yuwei Huang#, Liang Li, Yuanhu Ju, Daqing Lv, Xiaoyi Chen, Liyun Yuan*, Guoqing Zhang*. PreDigs: A Database of Context-specific Cell Type Markers and Precise Cell Subtypes for Digestive Cell Annotation. Genomics Proteomics Bioinformatics. 2025 Sep 22;23(4):qzaf066. doi: 10.1093/gpbjnl/qzaf066.

6. Wan Liu#, Pingping Wang#, Xinhao Zhuang#, Yunchao Ling, Haiyan Liu, Sheng Wang, Haihan Yu, Liangxiao Ma, Yuguo Jiang, Guoping Zhao, Xing Yan*, Zhihua Zhou*, Guoqing Zhang*. RDBSB: a database for catalytic bioparts with experimental evidence. Nucleic Acids Res 2025 Jan 6;53(D1):D709-D716.

7. Wenxing Gao#, Weili Lin#, Qiang Li#, Wanning Chen, Wenjing Yin, Xinyue Zhu, Sheng Gao, Lei Liu, Wenjie Li, Dingfeng Wu, Guoqing Zhang*, Ruixin Zhu*, Na Jiao*. Identification and validation of microbial biomarkers from cross-cohort datasets using xMarkerFinder. Nat Protoc 2024 Sep;19(9):2803-2830.

8. Yinzhao Wang#*, Liuyang Li#, Qiang Li#, Yaoxun Hu, Wenjie Li, Zhile Wu, Hungchia Huang, Zhenbo Lv, Wan Liu, Ruifang Cao, Guoping Zhao*, Fengping Wang*, Guoqing Zhang*. MASH-Ocean 1.0: Interactive platform for investigating microbial diversity, function, and biogeography with marine metagenomic data. iMeta 2024 May 19;3(3):e201.

9. Hanwen Zhou#, Liyun Yuan#, Yuanhu Ju, Yue Hu, Siqi Wang, Ruifang Cao, Zefeng Wang*, Guoqing Zhang*. IDeAS: an interactive database for dysregulated alternative splicing in cancers across Chinese and western patients. J Mol Cell Biol 2024 Apr 10;15(11):mjad074.

10. 凌鋆超#, 曹瑞芳#, 李亦学*, 张国庆*. 多组学大数据共享平台研究进展[J]. 生命科学, 2023,35(12):1553-1560.

11. Ruifang Cao, Yunchao Ling, Jiayue Meng, Ao Jiang, Ruijin Luo, Qinwen He, Anan Li, Yujie Chen, Zoutao Zhang, Feng Liu*, Yixue Li*, Guoqing Zhang*. SMDB: a Spatial Multimodal Data Browser. Nucleic Acids Res 2023 Jul 5;51(W1):W553-W559.

12. Yimin Wang#, Yunchao Ling#, Jiao Gong#, Xiaohan Zhao, Hanwen Zhou, Bo Xie, Haiyi Lou, Xinhao Zhuang, Li Jin, The Han100K Initiative§, Shaohua Fan*, Guoqing Zhang*, Shuhua Xu*. PGG.SV: a whole-genome-sequencing-based structural variant resource and data analysis platform. Nucleic Acids Res 2023 Jan 6;51(D1):D1109-D1116.

13. Ling Wang#, Wan Liu#, Jieliang Liang#, Linna Zhao, Qiang Li, Chenfen Zhou, Hui Cen, Qingbei Weng*, Guoqing Zhang*. Mining of novel secondary metabolite biosynthetic gene clusters from acid mine drainage. Sci Data 2022 Dec 9;9(1):760.

14. Yunchao Ling#, Ruifang Cao#, Jiaqiang Qian#, Jiefu Li, Haokui Zhou, Liyun Yuan, Zhen Wang, Liangxiao Ma, Guangyong Zheng, Guoping Zhao, Zefeng Wang*, Guoqing Zhang*, Yixue Li*.  An interactive viral genome evolution network analysis system enabling rapid large-scale molecular tracing of SARS-CoV-2. Sci Bull (Beijing) 2022 Apr 15;67(7):665-669.

15. Ning-ning Liu, Na Jiao, Jing-Cong Tan, Ziliang Wang, Dingfeng Wu, An-Jun Wang, Jie Chen, Liwen Tao, Chenfen Zhou, Wenjie Fang, Lo Hong Cheong, Weihua Pan, Wanqing Liao, Zisis Kozlakidis, Christopher Heeschen, Geromy G. Moore, Lixin Zhu*, Xingdong Chen*, Guoqing Zhang*, Ruixin Zhu*, Hui Wang*. Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts. Nat Microbiol 2022 Feb;7(2):238-250.

16. Weidi Huang#, Yunchao Ling#, Sirui Zhang, Qiguang Xia, Ruifang Cao, Xiaojuan Fan, Zhaoyuan Fang, Zefeng Wang*, Guoqing Zhang*. TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence. Nucleic Acids Res 2021 Jan 8;49(D1):D236-D242.

17. Yang Gao#, Chao Zhang#, Liyun Yuan#, YunChao Ling, Xiaoji Wang, Chang Liu,Yuwen Pan, Xiaoxi Zhang, Xixian Ma, Yuchen Wang, Yan Lu,Kai Yuan, Wei Ye,Jiaqiang Qian, Huidan Chang, Ruifang Cao, Xiao Yang, Ling Ma, Yuanhu Ju,Long Dai, Yuanyuan Tang, The Han100K Initiative§, Guoqing Zhang, Shuhua Xu*. PGG.Han: the Han Chinese genome database and analysis platform. Nucleic Acids Res 2020 Jan 8;48(D1):D971-D976.