| Oral administration of Lactobacillus kefiri Fanghua reduces immune senescence and aging phenotypes |
| 论文作者 |
Qiao, ZY; Zhang, YL; Liu, HH; Zou, H; Xie, QL; Liu, JS; Zhang, HC; Liu, TT; Liu, ZM; Qi, WW; Wu, H; You, CP |
| 期刊/会议名称 |
FOOD SCIENCE AND HUMAN WELLNESS |
| 论文年度 |
2025 |
| 论文类别 |
|
| 摘要 |
It has been suggested that immune senescence contributes to the aging of solid organs and that blocking immune senescence can alleviate the aging of organs. Aging is a systemic physiological change. It is currently difficult to achieve the goal of long-term delaying aging through drugs. Improving immunity and delaying aging through probiotics is a feasible research direction. Here, we first screened for a strain of Lactobacillus kefiri Fanghua (L. kefiri-FH) derived from Tibetan kefir and confirmed its function in restoring immunosuppression. Spleen weight, thymus weight, and whole blood cells were restored. The expression of programmed cell death-ligand 1 (PD-1), P16ink4a, and senescence-associated secretory phenotype (SASP)-related genes in the spleen and thymus was decreased. Second, we further confirmed the phenotype of L. kefiri-FH in improving solid organ function in 16-month-old mice as well as prolonging the lifespan of Caenorhabditis elegans. Mechanistically, whole genome sequencing and metabolomic analysis indicated that L. kefiri-FH contained three genes related to bile acid metabolism and increased lithocholic acid (LCA) in the intestine. We also confirmed that LCA increased G-protein-coupled bile acid receptor (Gpbar5 or TGR5) gene expression in dendritic cells (DCs) and inhibited the induction of T helper (Th) 1 and Th17 cells. Overall, our findings establish a causal relationship between the intestinal microenvironment, immune senescence, and solid organ aging, suggesting a way to regulate the intestinal microenvironment through diet, which thereby improves immune senescence and subsequently reduces solid organ aging. |
| 卷 |
14 |
| 影响因子 |
7.4 |
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