| Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis |
| 论文作者 |
Sun, L; Xu, XM; Du, HD; Lu, L; Imamura, F; Yang, QS; Chen, YP; Chen, Y; Pei, P; Yin, HY; Yang, L; Zong, G; Yu, CQ; Chu, QQ; Lv, J; Zhou, PC; Sun, DJY; Chen, JS; Gao, X; Li, LM; Chen, ZM; Lin, X |
| 期刊/会议名称 |
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY |
| 论文年度 |
2025 |
| 论文类别 |
|
| 摘要 |
Aims To determine dietary sources of odd-chain fatty acids (OCFAs) in Asians and their associations with cardiometabolic diseases (CMDs) and to compare these associations with other populations.Methods and results Erythrocyte fatty acids were profiled in 8185 participants (38% men, mean age 58.1 years) participating in the second resurvey of the China Kadoorie Biobank (CKB) in 2013-14 using gas chromatography. Correlations of pentadecanoic (15:0) and heptadecanoic (17:0) acids with dietary factors, assessed via food frequency questionnaires, were examined by Spearman correlations. During about 5-year follow-up, 950 incident CMD were recorded, including 387 ischemic heart disease (IHD), 127 diabetes, and 459 stroke. Cox regression yielded adjusted hazard ratios (HRs) for CMDs associated with levels of 15:0 and 17:0. These results were further meta-analysed with 33 additional prospective studies, involving 112 193 participants. OCFAs were significantly correlated with intakes of dairy products, wheat and coarse grains, and fish/seafood in the CKB. Both 15:0 and 17:0 were inversely associated with incident IHD, with adjusted HRs of 0.72 (95% CI 0.59-0.89) and 0.69 (0.56-0.86) for top vs. bottom tertile, respectively. Levels of 17:0 were also inversely associated with incident diabetes (0.41 [0.27-0.62]) and total CMDs (0.85 [0.74-0.97]). In the updated meta-analysis, both 15:0 and 17:0 levels showed inverse associations with diabetes, with pooled relative risks of 0.74 (0.68-0.80) and 0.65 (0.61-0.71) per 10th-90th percentile range, respectively. 17:0 was also inversely associated with incident IHD (0.87 [0.77-0.97]).Conclusion Our findings supported favourable associations between OCFAs and CMDs among populations with varied dietary sources and intake levels, which merits future intervention studies. This study underscores the potential for odd-chain fatty acids (OCFAs) 15:0 and 17:0 in cardiometabolic diseases, particularly in Asian populations where OCFAs were correlated with dietary fibre and fish besides dairy as indicated in Western populations with high dairy products. Clinically, these OCFAs could aid in risk stratification and dietary interventions, potentially guiding personalized nutrition to mitigate CMD risks. Key findings include the following:In Chinese with low dairy intake, our new evidence shows that OCFAs might serve as biomarkers of dietary fibre and fish intake besides dairy as indicated in Western studies with populations consumed high dairy products.Our findings suggest that erythrocyte 17:0 and/or 15:0 are associated with low risk of IHD and diabetes in the Asian population with varying dairy intake. OCFAs might serve as modifiable biomarkers for nutritional assessment, and their association with lower risk suggests their dietary sources are important to promote cardiometabolic health with diverse dietary sources.Meta-analysis supports the universal applicability of OCFAs as biomarkers, indicating their role in global health strategies. The modifiable features of OCFAs may offer a novel intervention strategy targeted raising their levels in high CMD risk population. |
| 影响因子 |
7.5 |
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