| ICAM-1 identifies preadipocytes and restricts white adipogenesis by adhering immune cells |
| 论文作者 |
Zheng, CX; Ye, JY; Yang, Q; Liu, KL; Chen, C; Cao, JC; Li, Q; Xue, YQ; Ma, H; Rabson, AB; Shao, CS; Hua, F; Sorokin, L; Melino, G; Shi, YF; Wang, Y |
| 期刊/会议名称 |
CELL DEATH AND DIFFERENTIATION |
| 论文年度 |
2025 |
| 论文类别 |
|
| 摘要 |
Adipose stem cell hierarchy was delineated by scRNA-seq analysis, revealing that ICAM-1, a glycoprotein that mediates cell-cell interaction, is a preadipocyte marker. However, the cellular and molecular mechanisms of how ICAM-1+ preadipocytes contribute to adipose tissue homeostasis in vivo remain unclear. To address this, Icam1+/CreERT2 mice were generated, and it was demonstrated that ICAM-1-expressing progenitors actively participated in developing and remodeling white adipose tissue. Under a high-fat diet, both proliferation and adipogenic differentiation of ICAM-1+ preadipocytes increased significantly. Interestingly, ICAM-1 plays a critical role in maintaining the interaction between preadipocytes and immune cells, acting as a checkpoint on white adipogenesis. Mice lacking ICAM-1 specifically in stromal cells exhibited worsened hyperplastic obesity, showing heightened fatty acid synthesis and lipid storage in adipose tissue, and the related insulin resistance. In human adipose tissue, ICAM-1 also marked committed preadipocytes and mediated adhesion between preadipocytes and immune cells. Thus, our study shows that ICAM-1 marks preadipocytes and curbs adipogenesis by facilitating adhesion between preadipocytes and immune cells. |
| 影响因子 |
15.4 |
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